10801-2 N Mo Pac Expressway, Ste 150 Austin, Texas 78759 512.345.7635
Private Practice Allergy and Asthma Center of Austin Austin, Texas
Fellowship Allergy and Immunology
Scripps Clinic and Research Foundation
La Jolla, California
July 1984-June 1986
Chief Clinical Fellow
Scripps Clinic and Research Foundation
La Jolla, California
June 1985-January 1986
Residency Internal Medicine
Scott and White Memorial Hospital
July 1982-June 1984
Internship Internal Medicine
Tulsa Medical College
University of Oklahoma
July 1981-June 1982
Allergy and Asthma Center
St. Petersburg, Florida
Allergy and Asthma Associates
Columbia, South Carolina
Clinical Assistant Professor Internal Medicine and Pediatrics
School of Medicine
University of South Carolina
Medical Director HealthQuest Therapy and Research Institute
Clinical Investigator CEDRA Research
Medical Director Lovelace Scientific Resources
Austin, Texas site
Medical Director Sirius Clinical Research 2007-2015
University of Texas Medical Branch
Galveston, Texas May 1981-MD
Undergraduate General Comparative Studies, Plan II
University of Texas, Austin May 1977-BA
Graduated Magna Cum Laude with Special Honors Plan II
University of Texas, Austin May 1977
Membership in Phi Beta Kappa Honor Society
University of Texas, Austin- May 1977
Date of Birth: January 19, 1955; Huntsville, Alabama
Family: Wife-Cynthia; Son-Billy; Daughter-Christy
Outside Interests:Guitar, bass, and other musical instruments, photography, web site development, family activities
Howland WC: Flucticasone propionate: topical or systemic effects? Clin Exp All 1996;26(3):18
Howland WC, Simon, RA: Sulfite-treated lettuce challenges in sulfite-sensitive subjects with asthma. J Allergy Clin Immunol 1989;83(6):1079.
Ferreri NR, Howland W, Stevenson DD, Spiegelber HL: Release of leukotrienes, prostaglandins, and histamine into nasal secretions of aspirin-sensitive asthmatics during reaction to aspirin. Ann Rev Respir Dis 1986;137(4):847.
Ferreri NR, Howland WC, Spiegelberg HL: Release of leukotrienes C4 and B4 and prostaglandin E2 from human monocytes stimulated with aggregated IgG, IgA, and IgE. J Immunol 1986;136(11):4418.
Lang DM, Howland WC: Solar sneeze reflex. JAMA 1987;257(10):1330. Letter.
Bernstein DI, Creticos PS, Busse WW, Cohen R, Graft DF, Howland WC, et al: Comparison of triamcinolone acetonide nasal inhaler with astemizole in the treatment of ragweed-induced allergic rhinitis. J Allergy Clin Immunol 1996;97(3):749.
Berkowitz RB, Dockhorn R, Lockey R, Findlay S, Howland WC, Mitchell DQ, Woehler T: Comparison of efficacy, safety, and skin test inhibition of cetirizine and astemizole. Ann Allergy 1996;76(4):363.
Howland WC, Dockhorn R, Gillman S, Gross GN, Hille D, Simpson B, Furst JA, Feiss G, Smith JA: A comparison of effects of triamcinolone acetonide aqueous nasal spray, oral prednisone, and placebo on adrenocortical function in male patients with allergic rhinitis. J Allergy Clin Immunol1996;98(2)302.
Prenner BM, Chervinsky P, Hampel FC, Howland WC, Lawrence M, Meltzer EO, Munk ZM Ratner PH, Seltzer JM, Settipane GA, Lorber RR, Harrison JE: Double-strength beclomethasone dipropionate (84mcg/spray) aqueous nasal spray in the treatment of seasonal allergic rhinitis. J Allergy Clin Immunol 1996;98(2):302.
Howland WC, et al: The efficacy of fluticasone propionate aqueous nasal spray for allergic rhinitis and its relationship to topical effects. Clin Therapeutics 18:6.
Weinstein S, Chervinsky P, Pollard SJ, Bronsky EA, Nathan RA, Prenner B, Howland WC, Stahl E, Liddle R,: A one-week dose-ranging study of inhaled salmeterol in children with asthma. J Asthma 1997;34(1):43.
Juniper EF, Howland WC, Roberts NB, Thompson AK, King DR, Math B: Measuring quality of life in children with rhinoconjunctivitis. J Allergy Clin Immunol 101:(2)(1)163.
Nathan RA, Mason J, Bernstein DI, Howland WC, Kaiser HB, Meltzer EO, Segall N: Long-Term Tolerability of Fexofenadine in Healthy Volunteers. Clin Drug Invest 1999 Oct;18(4):317-328.
Dockhorn R, Aaronson D, Bronsky E, Chervinsky P, Cohen R, Ehtessabian R, Finn A, Grossman J, Howland W, Kaiser H, Pearlman D, Sublett J, Ratner P, Settipane G, Sim T, Storms W, Webb R, Drda K, Wood C: Ipratropium bromide nasal spray 0.03% and beclomethasone nasal spray alone in combination for the treatment of rhinorrhea in perennial rhinitis. Ann Allergy Asthma Immunol 1999 Apr;82(4):349-59
Tashkin DP, Nathan RA, Howland WC, Minkwitz MC, Simonson SG, Bonuccelli CM: An evaluation of zafirlukast in the treatment pf asthma with exploratory subset analyses. J Allergy Clin Immunol 99;103:246-254.
Howland III WC, Lang DM, “Exercise and Rhinitis,” Allergic and Respiratory Disease in Sports Medicine, New York, NY: Marcel Dekker, Inc., 1997. 197 pp.
Banov CH, Howland III WC, Lumry WR: Once-daily budesonide via Turbuhaler improve symptoms in adults with persistent asthma. Ann Allergy Asthma Immunol 2001 June;86(6): 627-32.
Lang DM, Visintainer PF, Howland III WC, Stein M, Villareal M: Survey of the Extent and Nature of Care for Adults and Older Adults by Allergy/Immunology Practitioners. Ann Allergy Immunol 2000 Aug;85(2):106-109.
Ratner PH, Howland III WC, Arastu R, Philpot EE, Klein KC, Baidoo CA, Math M, Faris MA, PharmD, Rickard KA: Fluticasone propionate aqueous nasal spray provided significantly greater improvement in daytime and nighttime nasal symptoms of seasonal allergic rhinitis compared with montelukast. Ann Allergy Asthma Immunol 2003
Howland WC, Simon RA: Restaurant-provoked asthma: sulfite sensitivity. J Allergy Clin Immunol 75(1):45. Abstract.
Howland WC, Mathison DA, Fantozzi RD, Stevenson DD: Sinus surgery (ss) in aspirin sensitive asthmatic patients (asap). Ann Allergy 56:518. Abstract.
Ferreri NR, Howland WC, Spiegelberg HL: Release of leukotrienes C4 and B4 (LTC4, LTB4) and prostagladin E2 (PGE2) from human monocytes (Mo) induced wth aggregated immunoglobulines (Ig) of different classes. Abstract presented at FASEB National Meeting, April 1986.
Lang DM, Howland WC, Stevenson DD: Sensitivity and features of nasal cytology in diagnosis of allergic (IgE-mediated) rhinitis. Ann Allergy 60:176. Abstract.
Hampel F, Howland W, Martin B, et al. The efficacy of fluticasone propionate aqueous nasal spray for treatment of rhinitis is dependent on topical application. J Allergy Clin Immunol 93:165. Abstract.
Howland W, Segal A, Glass M, Minkwitz, ZENECA Pharmaceuticals Group: 6-Week Therapy with the oral leukotriene-receptor antagonist, ICI 204,219,in the treatment of asthma. J Allergy Clin Immunol 93:581. Abstract.
Prenner B, Chevinsky P, Hampel FC, Howland WC, Lawrence M, Meltzer FO, Munk ZM, Ratner PH, Seltzer J, Settipane GA, Lorber RL, Harrison JE: Double strength beclomethasone dipropionate (84mcg/spray) aqueous nasal spray in the treatment of seasonal allergic rhinitis (SAR). J Allergy Clin Immunol 95:218. Abstract.
Howland W, Field E, Harding S, Rogenes P, Pobiner B, Scott C, Milwee S, Hamedani A: Fluticasone propionate aqueous nasal spray (fpans) is an anti-rhinitic with topical but not systemic activity. J Allergy Clin Immunol 95:221. Abstract.
Shapiro G, Nathan R, Noonan M, Taylor J, DÃƒÆ’Ã†â€™, Alonzo G, Busse B, Howland W, Simon R, Robison A, Blosch C: Recombinant human 1L-1R (rhu 1L-1R) in adult patients with mild to moderate asthma. J Allergy Clin Immunol 95:848. Abstract.
Storms W, Howland WC, Sorkness CA, LaForce C, Goldstein M, Lincourt WR, Rogenes PR, Schaberg AE, Edwards L, FP HPA Axis Clinical Study Group: Fluticasone propionate (FP), triamcinolone acetonide (TAA) and Flunisolide (FLN) have similar effects of the HPA axis. J Allergy Clin Immunol 99:1304. Abstract.
Howland W, Birdsall D, Uryniak T, Casty FE, Intal Study Group: A twelve week placebo- controlled efficacy and safety study of Intal 1 mg formulated with CFC or HFA-227 as propellant for the treatment of asthma. J Allergy Clin Immunol 99:1321. Abstract.
Ratner PH, vanBavel JH, Martin BG, Hampel FC, Howland WC, Rogenes PR, Westlund R, Cook CK: The efficacy and safety of fluticasone propionate (FP) aqueous nasal spray and loratadine (LOR), alone and in combination, in the treatment of seasonal allergic rhinitis (SAR). J Allergy Clin Immunol 99:1784. Abstract.
Bowers B, Cox F, Howland W, Cook C, Westlund R, Rogenes P: Superior impact of intranasal fluticasone vs loratadine on work, home & leisure activities affected by SAR. J Allergy Clin Immunol 99:1785. Abstract.
Finn AF, Howland WC, Bronsky EA, Lumry WR, Pepsin PJ, Rogenes PR, Westlund R, Cook CK: The efficacy of three different dosig regimens of fluticasone propionate (FP) aqueous nasal spray in the treatment of perennial nonallergic rhinitis (PNAR). J Allergy Clin Immunol 99:1787.Abstract.
Pepsin PJ, Howland WC, Finn AF, Cox FM, Bowers BW, Montgomery E, Westlund R: Patient- related overall treatment satisfaction and effectiveness with three dosing regimens of intranasal fluticasone propionate (FP) in perennial non-allergic rhinitis (PNAR). J Allergy Clin Immunol 99:1796. Abstract.
Weinstein S, Chervinsky P, Pollard SJ, Bronsky EA, Nathan RA, Prenner B, Howland WC, Stahl E, Liddle R: A one-week dose-ranging study of inhaled salmeterol in children with asthma. J Asthma 34(1);43. Abstract.
Tashkin DP, Nathan RA, Howland III WC, Minkwitz MC. Efficacy of zafirlukast (Accolate): exploratory subset data from three 13-week multicenter trials. Am J Resp Critical Care Med 155:663. Abstract.
Howland III W, Kemp J, McClung G, Arledge T, Byrne A, St Cyr C, Stahl E. Salmeterol in the Diskus powder inhaler is effective and well tolerated in protecting against exercise-induced bronchospasm (EIB) in adolescents and adults with asthma. Am J Resp Critical Care Med 155:962. Abstract.
Tita J, LaForce C, Howland III WC, Noveck RJ, Tripathy I, Reed KD, Edwards LD, Schaberg A, Rogenes P. Use of 6-hr cosyntropin stimulation tests to evaluate potential effects of inhaled fluticasone propionate (FP), inhaled triamcinolone acetonide (TAA), placebo (PBO), and oral prednisone on HPA axis function. Am J Resp Critical Care Med 155:355. Abstract.
Harrison LI, Soria I, Machacek J, Jacobson J, Purrington A, Cline A, Grassell J, Dahl D, Wells T, Chang S, Howland W. Pharmacokinetic profile of improved drug delivery with CFC free ultrafine aerosol steroid inhaler. Am J Resp Critical Care Med 155:666. Abstract.
Harrison L, Soria I, Machacek J, Jacobson J, Purrington A, Cline A, McCarville S, Grassell J, Dahl D, Wells T, Chang S, Howland W. Pharamacokinetics of beclomethasone dipropionate from CFC-free ultrafine aerosol and conventional CFC inhalers in asthmatics. Thorax 1996;51(3):P193. Abstract.
Harrison L, Soria I, Machacek J, Jacobson J, Purrington A, Cline A, McCarville S, Grassell J, Dahl D, Wells T, Chang S, Howland W. Beclomethasone pharmacokinetics in asthmatics given CFC and CFC-free inhalers. European Resp J 19969(23):256s. Abstract.
Harrison L, Soria I, Cline A, Wells T, Chang S, Howland W: 200 mcg extrafine HFA beclonethasone dipropionate (HFA-BDP) demonstrates absorption similar total to 400 mcg of CFC-BDP. J Allergy Clin Immunol 101:(1)(2)S65.
Howland III WC, Pepsin PJ, Westlund R, Rogenes PR, Cook CK: Gender analysis of intranasal fluticasone propionate (FP) in patients with perennial non-allergic rhinitis (PNAR). J Allergy Clin Immunol 101:(1)(2) S248.
Howland III WC, Walton-Bowen K, Lampl K: Once-daily budesonide (Pulmicort Turbuhaler (R)) is safe and well tolerated in adult asthmatics with or without previous inhaled corticosteroid (ICS) use. ACAAI 1999. Ann Alllergy 2000; 84(1):161.
Shapiro GG, Howland III WC: Once-daily budesonide inhalation powder (Pulmicort Turbuhaler) is safe and well tolerated in children previously treated with inhaled corticosteroids. J Allergy Clin Immunol 2000; 105(No.1 Pt.2):S19.
Howland III WC, Ratner PH, Jacobs RL, Reed KD, Prillaman BA, Crim C, Cook CK: Fluticasone propionate aqueous nasal spray relieves sinus pain and pressure in patients with allergic rhinitis.J Allergy Clin Immunol 107:(2) S154.
van Bavel JH, Martin BG, Jacobs RL, Howland III WC, Prillaman BA, Goode-Sellers ST, Cook CK, Richard K: #P80 Fluticasone propionate aqueous nasal spray improves snoring in patients with sinus pain and pressure associated with nasal congestion due to allergic rhinitis. Ann Allergy 2001;86 (1):113
Ratner PH, Howland III WC, Jacobs RL, Reed KD, Goode-Sellers ST, Prillaman BA, Philpot EE, Cook CK: Relief of sinus pain and pressure with fluticasone propionate aqueous nasal spray: a placebo-controlled trial in patients with allergic rhinitis. Allergy Asthma Proc 2002;23 (4):259.